Disorders of the growth plate

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Differentiation is the cellular process that regulates development of long bones and joint surface cartilage of synovial cavities. Growth plate cartilage development is commonly referred to as endochondral ossification which is the end stage of long bone development. Endochondral ossification proceeds as a continuum of chondrocyte proliferation cycles followed by non-proliferative phases couple...

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We studied the cellular response to physeal distraction in the growth plates of skeletally immature rabbits. We used a new method of labelling and detection of proliferating cells with bromodeoxyuridine (BUdR) and an anti-BUdR antibody. The application of an external fixator but no distraction force produced no changes in the growth plates. After five days of distraction at a maximum force of 2...

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The Effects of Morphine on Tissue Structure of the Growth Plate in Male Rats

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The growth plate is a highly organized cartilage structure with a complex cellular biology. Studies have been limited by the relative lack of relevant experimental models. Thanks to new technologies, e.g. targeted deletions of genes, knowledge is rapidly expanding. The first paper selected representing the mechanism of the year describes how estradiol can rescue skeletal growth during GH resist...

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ژورنال

عنوان ژورنال: Current Opinion in Endocrinology, Diabetes and Obesity

سال: 2009

ISSN: 1752-296X

DOI: 10.1097/med.0b013e328331dca2